Preheat oven to 375°F (190°C). Line a large sheet pan with foil or parchment. Mix breadcrumbs and milk in a small bowl to form a panade.
In a large bowl, combine ground beef, panade, egg, onion, garlic, ketchup, Worcestershire sauce, Italian seasoning, salt, and pepper. Mix gently.
Shape mixture into an 8–9 inch loaf and place in the center of the prepared pan.
Toss potatoes with olive oil, garlic powder, herbs, salt, and pepper. Spread around the meatloaf.
Whisk together glaze ingredients and brush half over the meatloaf. Bake 25 minutes.
Remove pan, stir potatoes for even browning, brush remaining glaze over meatloaf, and bake another 20–25 minutes until internal temperature reaches 160°F (71°C).
Let meatloaf rest 5–10 minutes before slicing. Serve with roasted potatoes.
Notes
For a moist meatloaf, mix ingredients gently and let it rest before slicing. Serve with roasted vegetables or a salad.